Thermo Fisher Scientific Human MAPKAPK5 (PRAK), His Tag Recombinant Protein

Applications

• Kinase Assay (KA): Assay-dependent

Product Specifications

Product Specific Information

For maximum recovery, please spin prior to use.
Unless noted below, aliquots of the 5 µg, 10 µg, and 20 µg sizes of kinase are not recommended, as materials can be used in original packaging until exhausted.
For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots; aliquots below 20 µL are not recommended.
Do not store kinase diluted.
If properly stored at -80°C, this product is guaranteed for 6 months from the date of purchase.

Protein Form: Full Length

Target Information

MAPKAPK5 (PRAK) is activated in response to cellular stress and pro-inflammatory cytokines.
Activity of this kinase is regulated by p38 alpha and p38 beta.
The PRAK gene encodes a member of the serine/threonine kinase family.
Upon cellular stress and cytokine stimulation, it is activated through phosphorylation by MAP kinases such as MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta.
In vitro, this kinase phosphorylates heat shock protein HSP27 at physiologically relevant sites.
Two alternatively spliced transcript variants encoding distinct isoforms have been reported.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.