Thermo Fisher Scientific Human FLT3, His Tag Recombinant Protein

Thermo Fisher Scientific Human FLT3, His Tag Recombinant Protein

Applications

• Kinase Assay (KA)

Tested Dilution: Assay-dependent
Publications: -

Product Specifications

Product Specific Information

For maximum recovery, please spin prior to use.
Aliquots of 5 µg, 10 µg, and 20 µg sizes are not recommended; use materials in original packaging until exhausted.
For larger sizes, reduce freeze/thaw cycles by preparing aliquots (not below 20 µL).
Never store a kinase diluted.
If properly stored at -80°C, this product is guaranteed for 6 months from the date of purchase.

Protein Form: Recombinant, Catalytic Domain, Cytoplasmic

Target Information

FLT3 is a tyrosine protein kinase belonging to the growth factor receptor tyrosine kinase family.
Activation occurs upon binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, inducing homodimer formation and autophosphorylation.
The activated receptor phosphorylates and activates multiple cytoplasmic effector molecules involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow.
Mutations causing constitutive activation of this receptor lead to acute myeloid and lymphoblastic leukemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.