Thermo Fisher Scientific PLAUR Monoclonal Antibody (1D6)
Human PLAUR 단백질을 인식하는 Mouse IgG2a 단일클론 항체로 Western blot 및 ELISA에 적합. Affinity chromatography로 정제된 액상 형태이며 PBS buffer에 보존. 세포 표면 plasminogen 활성 조절 연구에 활용 가능.
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Thermo Fisher Scientific PLAUR Monoclonal Antibody (1D6)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 1–5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1D6 |
| Immunogen | PLAUR (AAH02788, 1–335 a.a.) full-length recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MGHPPLLPLL LLLHTCVPAS WGLRCMQCKT NGDCRVEECA LGQDLCRTTI VRLWEEGEEL ELVEKSCTHS EKTNRTLSYR TGLKITSLTE VVCGLDLCNQ GNSGRAVTYS RSRYLECISC GSSDMSCERG RHQSLQCRSP EEQCLDVVTH WIQEGEEGRP KDDRHLRGCG YLPGCPGSNG FHNNDTFHFL KCCNTTKCNE GPILELENLP QNGRQCYSCK GNSTHGCSSE ETFLIDCRGP MNQCLVATGT HEPKNQSYMV RGCATASMCQ HAHLGDAFSM NHIDVSCCTK SGCNHPDLDV QYRSGAAPQP GPAHLSLTIT LLMTARLWGG TLLWT
Target Information
The urokinase-type plasminogen activator receptor (PLAUR) is a key molecule involved in cell-surface plasminogen activation, playing crucial roles in normal and pathological processes. Human PLAUR cDNA encodes a 335 amino acid protein, including a signal peptide of 22 residues and a hydrophobic C-terminal portion. It forms a glycosylated protein (~50 kDa) anchored to the plasma membrane via glycosyl-phosphatidylinositol linkage.
PLAUR (UPAR) associates with SELL and β2 integrins on neutrophil membranes, mediating calcium mobilization dependent on SELL. UPAR mRNA levels correlate with invasive potential and disease progression in endometrial carcinomas, making UPAR a prognostic marker for advanced endometrial cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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