Thermo Fisher Scientific Human PRDM16 Synthetic Peptide
인간 PRDM16 단백질의 C-말단 17개 아미노산 서열에 해당하는 합성 펩타이드입니다. PRDM16 항체의 블로킹 실험에 사용 가능하며, 정제된 액상 형태로 제공됩니다. 연구용으로만 사용되며, MDS 및 AML 관련 연구에 적합합니다.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 17 amino acids near the carboxy terminus of human PRDM16.
PEP-0986 can be used as a blocking peptide with polyclonal antibody PA5-20872.
Target Information
PRDM16 is a zinc finger transcription factor containing an N-terminal PR domain.
The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML).
This gene is located near the 1p36.3 breakpoint and is specifically expressed in t(1:3)(p36,q21)-positive MDS/AML.
The translocation results in overexpression of a truncated version lacking the PR domain, which may contribute to MDS and AML pathogenesis.
PRDM16 acts as a Smad3 binding protein involved in orofacial development via TGF-beta signaling modulation and controls the cell fate switch between skeletal myoblasts and brown fat cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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