Thermo Fisher Scientific NEFM Monoclonal Antibody (OTI1A4), TrueMAB
인간 NEFM 단백질을 인식하는 마우스 단클론 항체로, Western blot 및 면역세포염색에 적합. 고순도 친화 크로마토그래피 정제, 액상 형태로 제공. 신경세포 마커 연구용으로 최적화된 TrueMAB 제품.
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Applications
- Western Blot (WB): 1:1,000–1:4,000
- Immunocytochemistry (ICC/IF): 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1A4 |
| Immunogen | Full length human recombinant NEFM protein produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Neurofilaments (NFs) are intermediate filaments expressed almost exclusively in neuronal cells, particularly in large axons. They consist of three polypeptide chains—NF-M (medium), NF-H (high), and NF-L (light)—that share structural similarity in their coiled-coil core domains but differ in their terminal regions. NF-M’s tail domain mediates interactions critical for axonal architecture. Phosphorylation and O-GlcNAcylation of NF-M regulate its filament formation and function. Antibodies to neurofilament subunits serve as valuable markers for neuronal cells due to their abundance and stability in the nervous system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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