Thermo Fisher Scientific CD254 (RANK Ligand) Polyclonal Antibody
CD254 (RANK Ligand) 폴리클로날 항체로 인간, 마우스, 랫트에 반응하며 Western blot 및 Immunocytochemistry에 적합합니다. 항원 친화 크로마토그래피로 정제된 고순도 항체로 세포 사멸 조절 및 T세포 의존 면역반응 연구에 활용됩니다.
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Thermo Fisher Scientific CD254 (RANK Ligand) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 51–100 of Human RANKL |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2803148 |
Product Specific Information
Purity is >95% by SDS-PAGE.
Target Information
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which acts as a ligand for osteoprotegerin and is a key factor for osteoclast differentiation and activation.
It functions as a dendritic cell survival factor and regulates T cell-dependent immune responses.
Activation of T cells induces expression of this gene, promoting osteoclastogenesis and bone loss.
This protein activates antiapoptotic kinase AKT/PKB through a complex involving SRC kinase and TRAF6, suggesting a role in apoptosis regulation.
Gene disruption in mice results in severe osteopetrosis, lack of osteoclasts, defects in T/B lymphocyte differentiation, and failure to form lobulo-alveolar mammary structures during pregnancy.
Two alternatively spliced transcript variants have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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