Thermo Fisher Scientific RAP1 Polyclonal Antibody
RAP1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF 등 다양한 응용 가능. 인간 반응성, 고순도 친화 크로마토그래피 정제, -20°C 보관, 연구용 전용 시약.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
- Publications: [References not provided]
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
- Publications: [References not provided]
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
- Publications: [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TERF2IP (Accession Q9NYB0), corresponding to amino acid residues G198–E248 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852529 |
Product Specific Information
Antibody detects endogenous levels of total RAP1.
Target Information
Human RAP1 is the first identified ortholog of the yeast telomeric protein scRap1, sharing three conserved sequence motifs. HRap1 localizes to telomeres and modulates telomere length via recruitment by TRF2 rather than direct telomere binding. The hRap1 cDNA encodes a 399 amino acid protein (~47 kDa) that does not interact with TRF1.
TRF2, containing a Myb-related DNA-binding motif, binds duplex TTAGGG repeats and localizes to telomeres on metaphase chromosomes. TRF2 helps maintain telomere structure, preventing senescence and apoptosis in certain mammalian cells when inhibited.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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