Thermo Fisher Scientific Phospho-JAK2 (Tyr119) Polyclonal Antibody
Phospho-JAK2 (Tyr119) 폴리클로날 항체로, 인간 JAK2의 인산화 부위(Tyr119)를 인식합니다. Western blot, IHC, ICC/IF에 사용 가능하며, 고특이성과 재현성을 제공합니다. 연구용으로 세포 신호전달 및 JAK2 관련 질환 연구에 적합합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human JAK2 around the phosphorylation site of Tyr119. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2903151 |
Target Information
Janus kinase 2 (JAK2) is a protein tyrosine kinase involved in specific cytokine receptor signaling pathways and is mutated in polycythemia vera. It contains the catalytic domain (JH1) of JAK2. Activation of JAKs leads to phosphorylation of STAT (signal transducers and activators of transcription) proteins, which dimerize and translocate to the nucleus to modify transcription of numerous genes, including interferon-stimulated genes. JAK2 is required for IFN gamma-receptor complex initiation, with JAK1 acting as an amplifier. Mutations in JAK2 can cause Budd-Chiari syndrome, polycythemia vera, thrombocythemia 3, myelofibrosis, or acute myelogenous leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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