Thermo Fisher Scientific Phospho-JAK2/JAK3 (Tyr966, Tyr939) Polyclonal Antibody
JAK2/JAK3 인산화 부위(Tyr966, Tyr939)를 인식하는 Rabbit Polyclonal Antibody로, WB 및 IHC(P) 실험에 적합합니다. 액상 형태, 1 mg/mL 농도이며 -20°C 보관. 세포 신호전달 연구용으로 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human JAK2/3 around the phosphorylation site of Tyr966/939 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2903152 |
Target Information
Janus Activating Kinase 2 and 3 (JAK2/JAK3) are tyrosine kinases involved in cytoplasmic signal transduction. In response to cytokines or related factors such as interferon and interleukins, JAKs are activated via phosphorylation at adjacent tyrosine residues. Activated JAKs phosphorylate STAT (Signal Transducers and Activators of Transcription) proteins, which dimerize and translocate to the nucleus to regulate transcription of interferon-stimulated genes.
JAK2 is required for IFN gamma-receptor complex initiation, while JAK1 functions as an amplifier. Active JAK1 may be required for complex responses, and studies suggest that Tyk2 and JAK3 may perform roles similar to JAK2 within the IFN gamma-receptor complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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