Thermo Fisher Scientific Prosapip1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human LZTS3. Recombinant protein control fragment (Product #RP-95502). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Prosapip1,uniProtId:O60299-1,ncbiNodeId:9606,antigenRange:284-380,antigenLength:673,antigenImageFileName:PA5-56613_Prosapip1_O60299-1_Rabbit.svg,antigenImageFileNamePDP:PA5-56613_Prosapip1_O60299-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2643659

Product Specific Information

Immunogen sequence: KSGSSSSMGR PGHLGSGEGG GGGLPFAACS PPSPSALIQE LEERLWEKEQ EVAALRRSLE QSEAAVAQVL EERQKAWERE LAELRQGCSG KLQQVAR

Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 98%.

Target Information

Prosapip1 is a binding partner of the postsynaptic density (PSD) protein ProSAP2/Shank3, a major scaffolding protein in excitatory brain synapses. Prosapip1 is thought to bind ProSAP2/Shank3 through a PDZ domain in ProSAP2/Shank3 and link it in turn to the Spine-associated Rap-Gap (SPAR). Prosapip1 shares significant homology with another PSD protein, PSD-Zip70, with both coding for a Fez1 domain that can be found in a total of four related protein, forming a novel family of scaffolding molecules termed Fezzins. Recent studies show that Prosapip1 can be found in endocrine cells in which it is localized primarily in the hormone-storing compartment of these cells, suggesting that Prosapip1 may have other functions in non-neuronal cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.