Thermo Fisher Scientific G0/G1 switch 2 Polyclonal Antibody
G0/G1 switch 2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ELISA, IP 등 다양한 응용 가능. 고순도 친화 크로마토그래피 정제 및 안정적인 액상 형태로 제공. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide taken within amino acid region 78–103 on mouse G0S2-like protein. The peptide was covalently modified to achieve desired antigenicity and conjugated to a carrier protein. Sequence: ALLAGGKAQEATLCSRALSLRQHAS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | –20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
The G(0)-G(1) switch gene 2 (G0S2) encodes a mitochondrial protein involved in apoptosis, lipolysis, and triacylglycerol hydrolysis. In adipocytes, G0S2 binds to adipose triglyceride lipase, reducing lipid droplet breakdown. In Crohn’s colitis, G0S2 expression correlates with non-converted lipid accumulation. Mutations in G0S2 are common in squamous lung cancer, while epigenetic silencing occurs in breast cancer, impairing apoptotic regulation. When active, G0S2 mediates Bcl-2/Bax heterodimer formation, promoting apoptosis in cancer cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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