Thermo Fisher Scientific Cripto-1 TDGF1 Polyclonal Antibody

Thermo Fisher Scientific Cripto-1 (TDGF1) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature.
This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.

This antibody is specific for human Cripto-1 protein. A BLAST analysis suggests limited cross-reactivity with Cripto-1 from mouse based on 70% homology with the immunizing sequence. Expect cross-reactivity with human Cripto-3 (TDGF2) due to high sequence conservation. Cross-reactivity with Cripto-1 from other sources has not been determined.

Target Information

Cripto (TDGF1) is a GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated TDGF1 acts as a Nodal coreceptor in cis. Shedding of TDGF1 by TMEM8A modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells.
TDGF1 is expressed both in embryonic stem cells and during early embryo development, and in adults it is reactivated in various epithelial cancers.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.