Thermo Fisher Scientific ATP8A2 Polyclonal Antibody
ATP8A2 단백질을 인식하는 Rabbit Polyclonal Antibody로, 인간 시료에 반응합니다. 면역세포화학(ICC/IF)에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS(glycerol 포함) 용액 형태로 제공되며, 단기 4°C, 장기 -20°C 보관이 권장됩니다.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human ATP8A2. Recombinant protein control fragment (Product # RP-105975) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2664926 |
Product Specific Information
Immunogen sequence:
GVTYGHFPELA REPSSDDFCR MPPPCSDSCD FDDPRLLKNI EDRHPTAPCI QEFLTLLAVC HTVVPEKDGD N
- Highest antigen sequence identity to the following orthologs:
- Mouse: 88%
- Rat: 89%
Target Information
Catalytic component of a P4-ATPase flippase complex that catalyzes ATP hydrolysis coupled to the transport of aminophospholipids from the outer to the inner leaflet of membranes, maintaining phospholipid asymmetry.
Phospholipid translocation is implicated in vesicle formation and lipid signaling molecule uptake.
The ATP8A2:TMEM30A complex primarily transports phosphatidylserine (PS) and, to a lesser extent, phosphatidylethanolamine (PE).
Functions in maintaining phospholipid asymmetry in photoreceptor disk and neuronal axon membranes, possibly involved in vesicle trafficking and neurite outgrowth regulation with TMEM30A.
Required for normal visual and auditory function, contributing to photoreceptor and spiral ganglion cell survival.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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