Thermo Fisher Scientific PD-L1 (CD274) Recombinant Rabbit Monoclonal Antibody (JJ08-95)
PD-L1 (CD274)에 특이적인 재조합 토끼 단클론 항체로, 높은 특이성과 감도를 제공. WB, IHC, ICC/IF 등 다양한 응용에 적합. 로트 간 일관성 및 동물 유래 성분 없는 제형. 인간, 마우스, 랫트 반응성.
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- MA532450
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JJ08-95 |
| Immunogen | Synthetic peptide within Human PD-L1 (aa 191–240) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809727 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broad immunoreactivity due to larger rabbit immune repertoire
Target Information
Programmed death receptor ligand 1 (PD-L1, also known as B7-H1) is a member of the B7 family. Its receptor, programmed death receptor 1 (PD-1), negatively regulates T-cell receptor (TCR) signaling. Upon receptor binding, PD-L1 decreases TCR-mediated proliferation and cytokine production. PD-L1 is abundantly expressed in many murine and human cancers and can be upregulated by IFN-gamma stimulation, suggesting its role in tumor immune evasion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지: MA5-32450_PD-L1_CD274_Q9NZQ7-1_Rabbit.svg)
(이미지: MA5-32450_PD-L1_CD274_Q9NZQ7-1_Rabbit_PDP.jpeg)
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