Thermo Fisher Scientific CDK12 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human CDK12. Recombinant protein control fragment (Product #RP-89808). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CDK12,uniProtId:Q9NYV4-1,ncbiNodeId:9606,antigenRange:1347-1468,antigenLength:1490,antigenImageFileName:PA5-82330_CDK12_Q9NYV4-1_Rabbit.svg,antigenImageFileNamePDP:PA5-82330_CDK12_Q9NYV4-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2789489

Product Specific Information

Immunogen sequence: GFSAIDTDER NSGPALTESL VQTLVKNRTF SGSLSHLGES SSYQGTGSVQ FPGDQDLRFA RVPLALHPVV GQPFLKAEGS SNSVVHAETK LQNYGELGPG TTGASSSGAG LHWGGPTQSS AY

Target Information

Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5-GTGACGT\[AG\]\[AG\]-3), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family. Isoform 4/ATF-A0acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter. Isoform 5/ATF-4acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.