Thermo Fisher Scientific PLA2R1 Recombinant Rabbit Monoclonal Antibody (7I4Z1)
PLA2R1 단백질을 표적으로 하는 Thermo Fisher의 재조합 토끼 단클론 항체로, Western blot과 ELISA에 적합합니다. HEK293 세포에서 발현되었으며, Protein A로 정제된 고순도 항체입니다. 인간, 마우스, 랫트 시료에 반응하며 -20°C에서 보관합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 7I4Z1 |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 810–910 of human PLA2R1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.92 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
Product Specific Information
Immunogen Sequence:
YQYDVPWLFY QDAEYLFHTF ASEWLNFEFV CSWLHSDLLT IHSAHEQEFI HSKIKALSKY GASWWIGLQE ERANDEFRWR DGTPVIYQNW DTGRERTVNN Q
Target Information
Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phospholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also binds to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2.
Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as:
- Activation of the MAPK cascade to induce cell proliferation
- Production of lipid mediators
- Selective release of arachidonic acid in bone marrow-derived mast cells
- Activation of p38 MAPK in neutrophils to stimulate elastase release and cell adhesion
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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