Thermo Fisher Scientific CSK Recombinant Rabbit Monoclonal Antibody (1H8L6)

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody is predicted to react with Monkey, Mouse, and Pig.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.

Key Advantages:

• Improved specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broad immunoreactivity due to larger rabbit immune repertoire

Target Information

CSK (C-terminal Src kinase) is a tyrosine kinase that downregulates SRC oncoprotein activity through phosphorylation of its carboxy terminus. Because SRC transformation results from disruption of this phosphorylation, the CSK gene may function as an antioncogene.

CSK regulates cell growth, differentiation, migration, and immune responses. It phosphorylates C-terminal tyrosine residues of Src-family kinases including LCK, SRC, HCK, FYN, LYN, CSK, and YES1. CSK is ubiquitously expressed (~50 kDa) in cytosol, with a fraction localized to lipid rafts via interaction with PAG (Csk-binding protein).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.