Thermo Fisher Scientific Cyclophilin B Monoclonal Antibody (CL3901)
Cyclophilin B 단백질을 검출하기 위한 Mouse 모노클론 항체(CL3901). Western blot 및 IHC(Paraffin)에 적합하며, Human, Mouse, Rat에 반응. Protein A 정제, PBS/glycerol buffer, 1 mg/mL 농도, 연구용 전용.
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Thermo Fisher Scientific Cyclophilin B Monoclonal Antibody (CL3901)
Applications and Tested Dilution
- Western Blot (WB): 1 µg/mL
- Immunohistochemistry (Paraffin) (IHC (P)): 1:5,000–1:10,000
- Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CL3901 |
| Immunogen | Synthetic peptide corresponding to Human PPIB |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C (avoid freeze/thaw cycles) |
| Shipping Conditions | Wet ice |
| RRID | AB_2787028 |
Product Specific Information
Immunogen sequence: TKTDSRDKPL KDVIIADCGK IEVEKPFAIA KE
Target Information
Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents—cyclosporin A (CsA) or FK506.
Proteins which bind FK506 are termed FK506 Binding Proteins (FKBPs), and those which bind cyclosporin A are called cyclophilins (CyPs).
Both CyP:CsA and FKBP:FK506 complexes inhibit calcineurin, a calcium/calmodulin-dependent protein phosphatase involved in T-cell activation, explaining their immunosuppressive effects.
Immunophilins act as peptidyl-prolyl cis-trans-isomerases (PPIases) that accelerate protein folding by catalyzing slow proline rearrangement steps.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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