Thermo Fisher Scientific ACE2 Monoclonal Antibody (CL4013)
인체 ACE2 단백질을 인식하는 Mouse IgG1 단일클론 항체입니다. Western blot 및 IHC(파라핀)에서 높은 특이성과 민감도를 보이며, SARS-CoV 및 심혈관 연구에 적합합니다. 단백질 A 정제, 액상 형태로 제공되며 장기 보관 시 -20°C에서 안정적입니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1 µg/mL
Immunohistochemistry (IHC)
- Tested Dilution: Not specified
- Publications: 3 publications available
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:10,000–1:20,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CL4013 |
| Immunogen | Recombinant protein corresponding to Human ACE2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2787030 |
Product Specific Information
Immunogen sequence:
MSSSSWLLLS LVAVTAAQST IEEQAKTFLD KFNHEAEDLF YQSSLASWNY NTNITEENVQ NMNNAGDKWS AFLKEQSTLA QMYPLQEIQN LTVKLQLQAL QQNGSSVLSE D
Target Information
Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. Unlike its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. ACE2 has also been identified as a functional receptor for the SARS coronavirus.
Its normal function is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII.
Lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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