Thermo Fisher Scientific Lass5 Polyclonal Antibody
Thermo Fisher Scientific의 Lass5 Polyclonal Antibody는 사람, 생쥐, 랫트 반응성을 가지며 WB, IHC, ICC/IF에 사용됩니다. 항원 친화 크로마토그래피로 정제된 비결합 액상 항체로, 세라마이드 합성 관련 LASS5 단백질 연구에 적합합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | 2.5 µg/mL | — |
| Immunocytochemistry (ICC/IF) | 20 µg/mL | — |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | An 18 amino acid peptide near the amino terminus of the human LASS5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage store at −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152546 |
Product Specific Information
- Suggested positive control: Rat brain tissue lysate
- PA5-20570 can be used with blocking peptide PEP-0690
Target Information
The LASS (longevity assurance homolog) family members represent a subgroup of the homeobox gene family and are highly conserved from yeasts to mammals. Six members (LASS1–6) are involved in ceramide synthesis during cell growth regulation and cancer differentiation.
LASS5 (also called Trh4) is a 392 amino acid endoplasmic reticulum multi-pass membrane protein functioning as a dihydro-ceramide synthase. It produces sphingolipids containing mainly N-linked palmitoyl-ceramide in a fumonisin B1-independent manner, using palmitoyl-CoA as an acyl donor.
LASS5 synthesizes C14, C16, and C18-ceramide and is predominantly expressed in lung epithelia. Recent studies indicate that LASS5 partially corrects growth and apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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