Thermo Fisher Scientific KLDC3 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:20–1:50
• Publications: N/A

Product Specifications

Product Specific Information

Immunogen sequence:
MLRWTVHLEG GPRRVNHAAV AVGHRVYSFG GYCSGEDYET LRQIDVHIFN AVSLRWTKLP PVKSAIRGQA PVVPYMRYGH STVLID

• Highest antigen sequence identity to orthologs: Mouse – 97%, Rat – 97%

Target Information

The BTB (Broad-Complex, Tramtrack and Bric a brac) domain, also known as the POZ (Poxvirus and Zinc finger) domain, is an N-terminal homodimerization domain containing multiple copies of kelch repeats and/or C2H2-type zinc fingers.
Proteins with BTB domains are involved in transcriptional regulation via control of chromatin structure and function.
Kelch domain-containing protein 3 (KLHDC3), also designated PEAS, contains 5 Kelch repeats and may be involved in meiotic recombination.
The KLHDC3 gene maps to chromosome 6, which includes about 1,200 genes within 170 million base pairs.
Deletion of part of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting a cancer susceptibility locus.
Other diseases associated with genes on chromosome 6 include porphyria cutanea tarda, Parkinson’s disease, Stickler syndrome, 21-hydroxylase deficiency, and maple syrup urine disease.
KLHDC3 protein is mainly expressed in cytoplasm and also found in meiotic chromatin.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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