Thermo Fisher Scientific KLDC3 Polyclonal Antibody
Thermo Fisher Scientific의 KLDC3 Polyclonal Antibody는 인간 KLDC3 단백질을 인식하는 토끼 IgG 항체로, IHC(P) 실험에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS와 글리세롤 용액 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PA556360
- 판매단위
- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:20–1:50
- Publications: N/A
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human KLDC3. Recombinant protein control fragment (Product #RP-94801) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Lot-Specific |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2643138 |
Product Specific Information
Immunogen sequence:
MLRWTVHLEG GPRRVNHAAV AVGHRVYSFG GYCSGEDYET LRQIDVHIFN AVSLRWTKLP PVKSAIRGQA PVVPYMRYGH STVLID
- Highest antigen sequence identity to orthologs: Mouse – 97%, Rat – 97%
Target Information
The BTB (Broad-Complex, Tramtrack and Bric a brac) domain, also known as the POZ (Poxvirus and Zinc finger) domain, is an N-terminal homodimerization domain containing multiple copies of kelch repeats and/or C2H2-type zinc fingers.
Proteins with BTB domains are involved in transcriptional regulation via control of chromatin structure and function.
Kelch domain-containing protein 3 (KLHDC3), also designated PEAS, contains 5 Kelch repeats and may be involved in meiotic recombination.
The KLHDC3 gene maps to chromosome 6, which includes about 1,200 genes within 170 million base pairs.
Deletion of part of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting a cancer susceptibility locus.
Other diseases associated with genes on chromosome 6 include porphyria cutanea tarda, Parkinson’s disease, Stickler syndrome, 21-hydroxylase deficiency, and maple syrup urine disease.
KLHDC3 protein is mainly expressed in cytoplasm and also found in meiotic chromatin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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