Thermo Fisher Scientific KLDC3 Polyclonal Antibody
Thermo Fisher Scientific의 KLDC3 폴리클로날 항체는 인간 KLDC3 단백질을 표적으로 하는 연구용 항체입니다. IHC(P) 및 ICC/IF에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며 4°C 또는 -20°C에서 안정적으로 보관 가능합니다.
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Thermo Fisher Scientific KLDC3 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human KLDC3. Recombinant protein control fragment (Product #RP-94799). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2643136 |
Product Specific Information
Immunogen sequence:
FHSATMLGSH MYVFGGRADR FGPFHSNNEI YCNRIRVFDT RTEAWLDCPP TPVLPEGRRS HSAFGYNGEL YIFGGYNARL NRHFHDLWKF NPVSF
Ortholog sequence identity:
- Mouse: 97%
- Rat: 97%
Target Information
The BTB (Broad-Complex, Tramtrack and Bric a brac) domain, also known as the POZ (Poxvirus and Zinc finger) domain, is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers.
Proteins with BTB domains are involved in transcriptional regulation via control of chromatin structure and function.
The Kelch domain-containing protein 3 (KLHDC3), also designated PEAS, contains 5 Kelch repeats and may be involved in the meiotic recombination process.
The gene encoding KLHDC3 maps to chromosome 6, which contains approximately 1,200 genes within 170 million base pairs.
Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting a cancer susceptibility locus.
Other diseases associated with genes on chromosome 6 include Porphyria cutanea tarda, Parkinson’s disease, Stickler syndrome, 21-hydroxylase deficiency, and maple syrup urine disease.
KLHDC3 protein is mainly expressed in the cytoplasm and also found in meiotic chromatin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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