Thermo Fisher Scientific ZIC1/ZIC2/ZIC3 Polyclonal Antibody
ZIC1/ZIC2/ZIC3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. WB, IHC, ICC/IF에 적합하며, 인간, 마우스, 랫트 반응성. 고순도(>95%) 항원 친화 크로마토그래피 정제. 연구용으로만 사용 가능.
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Thermo Fisher Scientific ZIC1/ZIC2/ZIC3 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 318–366 of human Zic1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553464 |
Product Specific Information
- Detects endogenous protein at a molecular weight of 51 kDa.
- Purity >95% by SDS-PAGE.
Target Information
Zic1 encodes a zinc finger protein expressed in the developing or matured central nervous system in a highly restricted manner. Zic is expressed in granule cells that make synaptic contact with Purkinje cells.
Zic1 is critical to cerebellar pattern formation. The expression of Zic genes begins at gastrulation and neurulation, becoming restricted to the dorsal neural ectoderm and dorsal paraxial mesoderm.
The Zic1 gene maps to chromosome 9 in mouse. Its 5′ flanking region contains a region-specific enhancer essential for expression regulation.
Zic2 and Zic3 are highly similar genes — Zic2 is essential for brain formation, and Zic3 is important for right-left axis formation.
The Drosophila odd-paired gene is highly homologous to the Zic gene family.
Usage Restriction
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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