Thermo Fisher Scientific CCDC98 Polyclonal Antibody
CCDC98(Abraxas 1) 단백질을 인식하는 Thermo Fisher Scientific의 토끼 다클론 항체입니다. Western blot, ELISA, IP에 적합하며, BRCA1 복합체 관련 연구에 유용합니다. 고순도 친화 크로마토그래피 정제 및 안정한 보관 용액 제공.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 350–400 of human BRCA1-A complex subunit Abraxas (CCDC98) protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CCDC98, also known as Abraxas 1, was identified through protein binding studies using the breast and ovarian predisposition protein BRCA1 as the binding target. CCDC98 recruits RAP80, a ubiquitin-binding protein, to BRCA1, enabling the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both CCDC98 and RAP80 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either CCDC98 or RAP80 exhibit increased sensitivity to ionizing radiation, though not as much as BRCA1-depleted cells, suggesting that CCDC98 and RAP80 control only part of BRCA1’s DNA damage response role. At least two isoforms of CCDC98 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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