Thermo Fisher Scientific CTCF Monoclonal Antibody (CL0304)
CTCF 단백질을 인식하는 Mouse IgG2a 단일클론 항체로, Western blot, IHC, ICC/IF에 적합합니다. 고순도 Protein A 정제, 액상 형태로 제공되며 PBS/glycerol buffer에 보존됩니다. 인간 시료 반응성이 높고 장기 보관 시 -20°C에서 안정적입니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:2,500 |
| Immunocytochemistry (ICC/IF) | 2–10 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CL0304 |
| Immunogen | Recombinant protein corresponding to Human CTCF (UniProt ID: P49711-1, antigen range: 42–189) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.7 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2786980 |
Product Specific Information
Immunogen sequence:
QNQTDGGEVV QDVNSSVQMV MMEQLDPTLL QMKTEVMEGT VAPEAEAAVD DTQIITLQVV NMEEQPINIG ELQLVQVPVP VTVPVATTSV EELQGAYENE VSKEGLAESE PMICHTLPLP EGFQVVKVGA NGEVETLEQG ELPPQEDP
Target Information
Transcriptional factor CTCF is a ubiquitously expressed 11-zinc finger domain-containing, DNA-binding nuclear phosphoprotein involved in multiple aspects of normal gene regulation, including transcriptional repression and activation, gene silencing, chromatin insulation, and regulation of imprinted sites.
CTCF interacts with the CCCTC motif on DNA using different combinations of zinc finger domains. It can bind to HAT- and HDAC-containing complexes, thereby influencing transcriptional activation or repression.
This multifunctional protein is involved in transactivation of the APPB gene, silencing of the c-myc gene, insulation of the human beta-globin and DMI myotonic dystrophy locus, and imprinting control of IGF2 and H19 regions.
CTCF also regulates transcription of Pax6 and IRAK2 promoters, offering potential therapeutic targets.
Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms’ tumors.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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