Thermo Fisher Scientific CTCF Monoclonal Antibody (CL0304)

Applications

Product Specifications

Product Specific Information

Immunogen sequence:
QNQTDGGEVV QDVNSSVQMV MMEQLDPTLL QMKTEVMEGT VAPEAEAAVD DTQIITLQVV NMEEQPINIG ELQLVQVPVP VTVPVATTSV EELQGAYENE VSKEGLAESE PMICHTLPLP EGFQVVKVGA NGEVETLEQG ELPPQEDP

Target Information

Transcriptional factor CTCF is a ubiquitously expressed 11-zinc finger domain-containing, DNA-binding nuclear phosphoprotein involved in multiple aspects of normal gene regulation, including transcriptional repression and activation, gene silencing, chromatin insulation, and regulation of imprinted sites.
CTCF interacts with the CCCTC motif on DNA using different combinations of zinc finger domains. It can bind to HAT- and HDAC-containing complexes, thereby influencing transcriptional activation or repression.
This multifunctional protein is involved in transactivation of the APPB gene, silencing of the c-myc gene, insulation of the human beta-globin and DMI myotonic dystrophy locus, and imprinting control of IGF2 and H19 regions.
CTCF also regulates transcription of Pax6 and IRAK2 promoters, offering potential therapeutic targets.
Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms’ tumors.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.