Thermo Fisher Scientific Bcl-X Polyclonal Antibody
Bcl-X 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Western blot 및 Immunohistochemistry에 적합합니다. 인간과 마우스 반응성이 있으며, 항원 친화 크로마토그래피로 정제되었습니다. 세포질 내 위치 검출에 유용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 2–10 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide derived from N-terminus of human BCL-X protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Raji cells
- Cellular location: Cytoplasmic
Target Information
The protein encoded by the BCL-X gene belongs to the BCL-2 protein family. These family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators involved in various cellular activities.
They are located at the outer mitochondrial membrane and regulate the VDAC channel, which controls mitochondrial membrane potential, reactive oxygen species production, and cytochrome C release — key factors in apoptosis induction.
Alternative splicing produces multiple transcript variants encoding two isoforms:
- The longer isoform acts as an apoptotic inhibitor.
- The shorter isoform acts as an apoptotic activator.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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