Thermo Fisher Scientific KREMEN2 Polyclonal Antibody
KREMEN2 단백질을 표적으로 하는 Thermo Fisher Scientific의 폴리클로날 항체입니다. Western blot에 적합하며 마우스에 반응합니다. 항원 친화 크로마토그래피로 정제된 고순도 제품으로, PBS 버퍼에 보존되어 연구용으로 사용됩니다.
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Thermo Fisher Scientific KREMEN2 Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide derived from the internal region of human, mouse and rat Kremen2 proteins |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533358 |
Target Information
Kremen (Kringle containing protein marking the eye and the nose) proteins are type I transmembrane proteins that contain extracellular kringle, WSC, and CUB domains and an intracellular region without any conserved motifs. Kremens bind a subset of the secreted Dickkopf proteins (Dkk 1, 2, and 4) with high affinity to modulate the canonical Wnt signaling pathway that is transduced by the ternary receptor complex composed of Wnt, Frizzled, and the LDL receptor related protein 5/6 (LRP5/6) co-receptor.
Recent experiments have shown that KREMEN2 is a regulator of bone remodeling and raise the possibility that antagonizing KREMEN2 might prove beneficial in patients with bone loss disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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