Thermo Fisher Scientific IRS1 Polyclonal Antibody
Thermo Fisher Scientific의 IRS1 Polyclonal Antibody는 인간 및 생쥐 시료에서 IRS-1 단백질 검출에 사용됩니다. Western blot에서 검증되었으며, 항원 친화 크로마토그래피로 정제되었습니다. PBS/BSA 버퍼에 보관되며, 연구용으로 적합합니다.
- 카탈로그번호
- PA11058
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 2 µg/mL | View 3 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues L(602)HTDDGYMPMSPGV(615) of human IRS-1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_325027 |
Product Specific Information
- PA1-1058 detects IRS-1 in mouse and human cells.
- Successfully used in Western blot procedures.
- Detects an approximately 170 kDa protein representing IRS-1 in 3T3 L1 cell extract.
- Immunogen: synthetic peptide corresponding to residues L(602)HTDDGYMPMSPGV(615) of human IRS-1.
- The immunizing peptide is 92% conserved in rats and mice.
- This peptide (Cat. # PEP-192) is available for use in neutralization and control experiments.
Target Information
IRS-1 (Insulin Receptor Substrate 1) is a major substrate of the insulin receptor, phosphorylated in response to insulin, IGF-1, and IL-4 stimulation. It is phosphorylated on serine, threonine, and tyrosine residues across various tissues. Casein kinase II mediates part of the insulin-stimulated phosphorylation, with Thr502 and Ser99 identified as key phosphorylation sites. IRS-1 contains three putative 14-3-3 binding sites (Ser270, Ser374, Ser641), with Ser270 located within the phosphotyrosine binding domain responsible for interaction with the insulin receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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