Thermo Fisher Scientific PD-L1/PDCD1LG1/CD274/B7-H1 (Cancer Immunotherapy Target) Recombinant Rabbit Monoclonal Antibody (PDL1/4451R)
PD-L1(Recombinant Rabbit Monoclonal Antibody)는 암 면역치료 연구용 항체로 인간 및 마우스에 반응합니다. Western blot, IHC, ICC, Flow cytometry 등 다양한 응용에 적합하며, HEK293 발현 시스템을 사용해 제조되었습니다. 단백질 A/G로 정제된 액상형 항체입니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | PDL1/4451R |
| Immunogen | Recombinant fragment (around aa 39–191) of human CD274 (PD-L1) protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a recently described B7 family member. To date, one specific receptor has been identified that can be ligated by PD-L1. This receptor, programmed death receptor 1 (PD-1), negatively regulates T-cell receptor (TCR) signaling. Upon ligating its receptor, PD-L1 has been reported to decrease TCR-mediated proliferation and cytokine production. PD-L1 expression is abundant in many murine and human cancers and can be further upregulated upon IFN-gamma stimulation. Thus, PD-L1 may play an important role in tumor immune evasion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: 29126-RBM11-P0_PD-L1_CD274_Q9NZQ7-1_Rabbit.svg, 29126-RBM11-P0_PD-L1_CD274_Q9NZQ7-1_Rabbit_PDP.jpeg)
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