Thermo Fisher Scientific Phospho-Tau (Ser199) Recombinant Superclonal Antibody (2HCLC)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They consist of multiple different recombinant monoclonal antibodies, combining the sensitivity of polyclonal antibodies with the specificity and consistency of monoclonal antibodies.
These antibodies recognize multiple epitope sites on the target, providing enhanced detection sensitivity for low-abundance targets.
Each lot contains a defined mixture of light and heavy chains, enabling reproducible production and eliminating biological variability seen in traditional polyclonal antibodies.
Note: Formerly called “Recombinant polyclonal antibody,” this product is now rebranded as “Recombinant Superclonal™ antibody.” The physical product and performance remain unchanged.

Target Information

Tau is a neuronal microtubule-associated protein primarily located on axons. It promotes tubulin polymerization and stabilizes microtubules.
The C-terminus binds axonal microtubules, while the N-terminus binds neural plasma membrane components, functioning as a linker between both.
Tau localization determines axonal polarity within neurons. Short isoforms contribute to cytoskeletal plasticity, while longer isoforms aid stabilization.
Hyper-phosphorylated Tau is the main component of paired helical filaments (PHF) found in neurofibrillary lesions in Alzheimer’s disease (AD) brains.
Phosphorylation impairs microtubule binding, leading to destabilization and neuronal degeneration.
Tau is phosphorylated by several kinases, including GSK-3β, PKA, cdk5, and casein kinase II.
Hyper-phosphorylated Tau also appears in other CNS disorders such as Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.