Thermo Fisher Scientific Podoplanin Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• Positive Samples: Mouse lung, Mouse brain, Rat kidney
• Cellular Location: Cell projection, membrane, single-pass type I membrane protein, filopodium membrane, lamellipodium membrane, microvillus membrane, ruffle membrane

Immunogen sequence:
ASTGQPEDDT ETTGLEGGVA MPGAEDDVVT PGTSEDRYKS GLTTLVATSV NSVTGIRIED LPTSESTVHA QEQSPSATAS NVATSHSTEK VDGDTQTTVE KDGLSTVTL

Target Information

Podoplanin (PDPN, T1A, gp38, Aggrus) is a mucin-type 1 glycoprotein with a molecular weight of 40–43 kDa. It is expressed in many tumors and normal cells, especially lymphatic epithelial cells and follicular dendritic cells. Podoplanin localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells.

As a regulator of the lymphatic endothelium, podoplanin likely contributes to maintaining the unique shape of podocytes. It serves as a ligand for CLEC-2 and its expression correlates with tumor invasiveness and metastatic potential. Podoplanin is involved in cell migration, metastasis formation, and tumor invasion.

Expression can be induced by Src activation of Cas, and recent findings suggest its presence on Th17 cells. Studies show podoplanin on a small but distinct population of CD4+ cells from human PBMC. Dysfunction of podoplanin has been linked to lymphangioma and subglottis neoplasm. It is also proposed as a marker for lung injury due to its physiological role.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.