Thermo Fisher Scientific PXR Polyclonal Antibody
Thermo Fisher Scientific의 PXR Polyclonal Antibody는 인간 PXR 단백질을 인식하는 Rabbit IgG 기반 항체로, WB, IHC, ICC/IF, Flow Cytometry에 적합합니다. 고순도 Protein A 및 항원 친화 크로마토그래피로 정제되었으며, 연구용으로만 사용됩니다.
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Applications 및 Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 | - |
| Immunocytochemistry (ICC/IF) | 1:10–1:50 | - |
| Flow Cytometry (Flow) | 1:10–1:50 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 100–127 amino acids from the central region of human NR1I2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2718405 |
Target Information
This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by compounds such as dexamethasone and rifampicin that induce CYP3A4 expression. Several alternatively spliced transcripts encoding different isoforms have been described, some using non-AUG translation initiation codons. Additional transcript variants exist but have not been fully characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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