Thermo Fisher Scientific ATF6 Polyclonal Antibody
ATF6 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF, Flow cytometry에 사용 가능. 고순도 Protein A 및 항원 친화 크로마토그래피로 정제. 인간 시료 반응, 연구용 전용.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:16,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000 | - |
| Immunocytochemistry (ICC/IF) | - | 1 publication |
| Flow Cytometry (Flow) | 1:10–1:50 | 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 350–377 amino acids of human ATF6 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2718408 |
Target Information
ATF6 is a transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response (UPR) target genes. It binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) and ERSE II sequences. Binding to ERSE requires NF-Y interaction.
ATF6 exists as homodimers and heterodimers with ATF6 beta and interacts with transcription factors such as NF-YC, GTF2I, YY1, and SRF. Under ER stress, the cleaved N-terminal domain translocates into the nucleus, where it functions as a transcription activator.
ATF6 belongs to the bZIP family, is N-glycosylated, and can be phosphorylated by MAPK14/P38MAPK.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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