Thermo Fisher Scientific CD146 Polyclonal Antibody
CD146 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC(Paraffin) 실험에 적합. Protein A 및 항원 친화 크로마토그래피로 정제됨. Human 시료 반응성. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:10–1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 532–558 amino acids from the C-terminal region of human MCAM |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2542105 |
Target Information
CD146 (MCAM) is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. It is expressed at cell-cell junctions in endothelial cells and other normal and malignant cell types. CD146 functions as a calcium-independent adhesion molecule and may also act in signal transduction through Fyn kinase, influencing tyrosine phosphorylation and actin cytoskeleton assembly. It plays roles in endothelial cohesion, melanoma cell interaction with vascular elements, and may participate in neural crest cell adhesion during embryonic development. CD146 also acts as a surface receptor that triggers phosphorylation of FYN and PTK2, and transiently increases intracellular calcium concentration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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