Thermo Fisher Scientific Aminoacylase Polyclonal Antibody
Thermo Fisher의 Aminoacylase Polyclonal Antibody는 Mouse ACY1 단백질을 인식하는 Rabbit IgG 항체입니다. WB, IHC, ELISA, IP 등 다양한 응용에 사용 가능하며, 보존제가 없는 형태로 제공됩니다. 단기 4°C, 장기 -20°C 보관을 권장합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:2,500–1:10,000 |
| Immunohistochemistry (Frozen) (IHC-F) | - |
| ELISA | 1:25,000–1:50,000 |
| Immunoprecipitation (IP) | 0.2–1 µL/mg of lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Mouse Aminoacylase-1/ACY1 Protein (Met1–Ser408) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2788527 |
Product Specific Information
This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Mouse Aminoacylase-1/ACY1.
Target Information
ACY1 encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group. It is involved in the catabolism and salvage of acylated amino acids.
The gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC). Expression is often reduced or undetectable in SCLC cell lines and tumors.
Human aminoacylase-1 is highly homologous to the porcine counterpart and is the first member of a new family of zinc-binding enzymes.
Mutations cause aminoacylase-1 deficiency, a metabolic disorder with CNS defects and increased urinary excretion of N-acetylated amino acids.
Alternative splicing results in multiple transcript variants, and read-through transcription occurs between this gene and ABHD14A. A pseudogene is located on chromosome 18.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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