Thermo Fisher Scientific Aminoacylase Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Mouse Aminoacylase-1/ACY1.

Target Information

ACY1 encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group. It is involved in the catabolism and salvage of acylated amino acids.
The gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC). Expression is often reduced or undetectable in SCLC cell lines and tumors.
Human aminoacylase-1 is highly homologous to the porcine counterpart and is the first member of a new family of zinc-binding enzymes.
Mutations cause aminoacylase-1 deficiency, a metabolic disorder with CNS defects and increased urinary excretion of N-acetylated amino acids.
Alternative splicing results in multiple transcript variants, and read-through transcription occurs between this gene and ABHD14A. A pseudogene is located on chromosome 18.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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