Thermo Fisher Scientific KLC2 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Immunogen sequence:
TLEDCASRNR KQGLDPASQT KVVELLKDGS GRRGDRRSSR DMAGGAGPRS ESDLEDVGPT AEWNG

Highest antigen sequence identity to orthologs:

• Mouse: 80%
• Rat: 88%

Target Information

Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26S proteasome are coupled to multiple copies of ubiquitin. Attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity.

Deubiquitination is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families:

• Ubiquitin C-terminal hydrolases
• Ubiquitin-specific processing proteases (USPs)
• OTU-domain ubiquitin-aldehyde-binding proteins
• Jab1/Pad1/MPN-domain-containing metallo-enzymes

Among these, USPs are the most widespread and conserved across evolution. They release ubiquitin from conjugated proteins and contain conserved catalytic domains with Cys and His boxes, as well as variable N- or C-terminal extensions involved in substrate recognition and protein interactions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.