Thermo Fisher Scientific FCGR3A Polyclonal Antibody, MaxPab
인간 FCGR3A 단백질을 인식하는 토끼 폴리클로날 항체. Western blot 및 in situ PLA 분석에 적합. 친화 크로마토그래피로 정제되었으며, PBS(pH 7.4)에 보존제 없이 제공. -20°C 보관, 반복 동결·해동 피해야 함.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| in situ PLA (PLA) | 1:1200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | FCGR3A (AAH36723.1, 1 a.a. ~ 290 a.a) full-length human protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein Sequence:
MGGGAGERLF TSSCLVGLVP LGLRISLVTC PLQCGIMWQL LLPTALLLLV SAGMRTEDLP KAVVFLEPQW YRVLEKDSVT LKCQGAYSPE DNSTQWFHNE SLISSQASSY FIDAATVDDS GEYRCQTNLS TLSDPVQLEV HIGWLLLQAP RWVFKEEDPI HLRCHSWKNT ALHKVTYLQN GKGRKYFHHN SDFYIPKATL KDSGSYFCRG LVGSKNVSSE TVNITITQGL AVSTISSFFP PGYQVSFCLV MVLLFAVDTG LYFSVKTNIR SSTRDWKDHK FKWRKDPQDK
Target Information
CD16 (FCGR3A) encodes a receptor that recognizes the Fc portion of immunoglobulin G (IgG). It plays roles in:
- Clearance of immune complexes from circulation
- Cellular mediated cytotoxicity
- Enhancement of viral infection
The FCGR3A gene shares high similarity with FCGR3B, located nearby on chromosome 1.
- FCGR3A: Expressed on natural killer (NK) cells as an integral membrane glycoprotein
- FCGR3B: Expressed on polymorphonuclear neutrophils (PMN) via phosphatidylinositol (PI) linkage
Mutations in FCGR3A are associated with:
- Immunodeficiency 20
- Susceptibility to recurrent viral infections
- Systemic lupus erythematosus
- Alloimmune neonatal neutropenia
Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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