Thermo Fisher Scientific FCGR3A Monoclonal Antibody (2B11)
인간 CD16(FcγRIIIa)을 인식하는 Mouse IgG2a monoclonal antibody. Western blot 및 ELISA에 적합하며, 비결합형 액상 형태로 제공. PBS buffer에 보존제 없이 저장하며, -20°C에서 보관 필요. 면역 복합체 제거 및 NK cell 연구에 유용.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 1 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2B11 |
| Immunogen | FCGR3A (AAH17865.1, 17 a.a. ~ 254 a.a) full-length recombinant protein with GST tag (GST tag MW: 26 KDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
GMRTEDLPKA VVFLEPQWYR VLEKDSVTLK CQGAYSPEDN STQWFHNESL ISSQASSYFI DAATVDDSGE YRCQTNLSTL SDPVQLEVHI GWLLLQAPRW VFKEEDPIHL RCHSWKNTAL HKVTYLQNGK GRKYFHHNSD FYIPKATLKD SGSYFCRGLV GSKNVSSETV NITITQGLAV STISSFFPPG YQVSFCLVMV LLFAVDTGLY FSVKTNIRSS TRDWKDHKFK WRKDPQDK
Target Information
CD16 encodes a receptor that recognizes the Fc portion of immunoglobulin G and is involved in the clearance of immune complexes from the circulation, as well as other functions such as cellular mediated cytotoxicity and enhancement of virus infections.
This gene, FCGR3A, shares high similarity with FCGR3B, located on chromosome 1.
- FCGR3A: Expressed on NK cells, anchored via transmembrane peptide
- FCGR3B: Expressed on PMN cells, anchored via phosphatidylinositol (PI) linkage
Mutations in FCGR3A are associated with:
- Immunodeficiency 20
- Susceptibility to recurrent viral infections
- Systemic lupus erythematosus
- Alloimmune neonatal neutropenia
Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Diseases associated with FCGR3A include Immunodeficiency 20 and Herpes Zoster.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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