Thermo Fisher Scientific USP37 Polyclonal Antibody
USP37 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal antibody로, WB, IHC, ICC/IF 등 다양한 응용에 사용 가능. 인간 및 랫트 반응성. 액상 형태, 1 mg/mL 농도, -20°C 보관. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human USP37 (Accession Q86T82), corresponding to amino acid residues P760–E810 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850201 |
Product Specific Information
Antibody detects endogenous levels of total USP37.
Target Information
USP37 is a deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. It specifically mediates deubiquitination of Lys-11-linked polyubiquitin chains, a ubiquitin-linkage type mediated by the APC/C complex, and also acts on Lys-48-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes deubiquitinase activity, preventing degradation of cyclin-A. USP37 also stabilizes the licensing factor CDT1, playing a key role in DNA replication regulation. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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