Thermo Fisher Scientific PSD93 Polyclonal Antibody
PSD-93 단백질을 검출하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF 등 다양한 응용에 사용 가능. 인간, 생쥐, 랫트 반응성. 항원 친화 크로마토그래피로 정제된 고품질 항체.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 3–5 µg/mL | View 2 publications |
| Immunohistochemistry (Frozen) (IHC (F)) | 5 µg/mL | - |
| Immunocytochemistry (ICC/IF) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues N(352) K L C D K P A S P R H Y S P(366) of human PSD-93 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2092050 |
Product Specific Information
PA1-043 detects Post Synaptic Density 93 (PSD-93) from rat and human tissues. This antibody does not detect other synapse-associated protein family members.
PA1-043 has been successfully used in Western blot and immunohistochemistry procedures.
By Western blot, this antibody detects an ~110 kDa protein representing PSD-93 in rat brain extract.
Immunohistochemical staining of PSD-93 in rat cerebellum with PA1-043 yields a pattern consistent with post-synaptic localization.
The PA1-043 immunogen is a synthetic peptide corresponding to residues N(352) K L C D K P A S P R H Y S P(366) of human PSD-93. This sequence is completely conserved in human PSD-93.
PA1-043 immunizing peptide (Cat. # PEP-021) is available for use in neutralization and control experiments.
Target Information
PSD-93, also known as chapsyn-110, is one of a family of plasma membrane-associated proteins found in synaptic junctions.
It is uniquely expressed in Purkinje neuron cell bodies and dendrites. PSD-93 has three ~90 amino acid repeats called PDZ domains, a single interior SH3 domain, and a carboxyl-terminal guanylate kinase homology (GuK) domain that is enzymatically inactive.
PDZ-domain interactions are thought to play a role in receptor and channel clustering, contributing to neuronal plasticity.
PSD-93 participates in clustering of certain proteins, including NMDA receptors and shaker-type potassium channels at the synaptic membrane.
NMDA receptors and shaker-type potassium channels share C-terminal sequence homology consisting of a threonine/serine-X-valine-COOH (T/SXV) motif, enabling PDZ-domain binding.
Neuronal nitric oxide synthase (nNOS), which lacks this motif but has its own PDZ domain, can interact with PSD-93 through a pseudo-homotypic PDZ-PDZ interaction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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