Thermo Fisher Scientific AKAP8L/HA95 Polyclonal Antibody
Human AKAP8L 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. IHC 및 IHC(P) 실험에 적합하며 항원 친화 크로마토그래피로 정제됨. TBS 버퍼에 0.1% BSA 포함, 4°C 보관. 연구용으로만 사용.
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Applications
Immunohistochemistry (IHC)
- Tested Dilution: 1:50–1:500
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 596 and 646 of human A kinase (PRKA) anchor protein 8-like (helicase A-binding protein 95 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
- Based on 100% sequence identity, this antibody is predicted to react with Gorilla, Chimpanzee, Northern white-cheeked gibbon, Naked mole rat, and Chinese hamster.
Target Information
AKAP8L may play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9, increasing CTE-dependent nuclear unspliced mRNA export. It is proposed to target PRKACA to the nucleus and may be involved in nuclear envelope breakdown, chromatin condensation, and anchoring of nuclear membranes to chromatin. It may regulate the initiation phase of DNA replication when associated with TMPO isoform Beta and is required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells, AKAP8L recruits HDAC3 to chromatin, leading to deacetylation and phosphorylation at Ser-10 of histone H3. It may also be involved in regulation of pre-mRNA splicing.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지: IHC-00277_AKAP8L_Q9ULX6-1_Rabbit.svg, IHC-00277_AKAP8L_Q9ULX6-1_Rabbit_PDP.jpeg)
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