Thermo Fisher Scientific NOX1 Polyclonal Antibody
Thermo Fisher Scientific의 NOX1 Polyclonal Antibody는 인간 NOX1 단백질을 표적으로 하는 토끼 폴리클로날 항체입니다. Western blot 및 IHC(P)에서 검증되었으며, 항원 친화 크로마토그래피로 정제되었습니다. 세포 내 산화환원 연구 및 pH 조절 관련 연구에 적합합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | 15 amino acid peptide near the center of human NOX1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2554635 |
Product Specific Information
A recommended positive control is 293 cell lysate.
Target Information
Voltage-gated proton (hydrogen) channels play an important role in cellular defense against acidic stress.
NOX1 is a homolog of the catalytic subunit of the superoxide-generating NADPH oxidase of phagocytes, gp91phox.
Three splice variants of NOX1 have been identified: NOH-1L, NOH-1S, and NOH-1Lv.
- NOH-1S: Voltage-gated proton channel involved in pH regulation, blocked by zinc.
- NOH-1L: Pyridine nucleotide-dependent oxidoreductase that generates superoxide and may conduct H⁺ ions as part of its electron transport mechanism.
- NOH-1S: Does not contain an electron transport chain.
NOX1 may have potential therapeutic relevance in ischemic disease research.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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