Thermo Scientific™

GeneBLAzer™ M1-NFAT-bla Jurkat Cells

GeneBLAzer™ M1-NFAT-bla Jurkat cells contain the human Acetylcholine (muscarinic) subtype 1 receptor (M1) stably integrated into the CellSensor™ NFAT-bla Jurkat자세히 알아보기

GeneBLAzer™ M1-NFAT-bla Jurkat cells contain the human Acetylcholine (muscarinic) subtype 1 receptor (M1) stably integrated into the CellSensor™ NFAT-bla Jurkat cell line. CellSensor™ NFAT-bla Jurkat cells (Cat. No. K1077) contain a beta-lactamase (bla) reporter gene under control of the Nuclear Factor of Activated T-cells (NFAT) response element.

M1-NFAT-bla Jurkat cells are functionally validated for Z`-factor and EC50 concentrations of carbachol. In addition, M1-NFAT-bla CHO-K1 cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.

In the brain, M1 activation mediates slow neuronal excitability. Cortical and hippocampal muscarinic receptors are thought to be important in the attentional aspects of cognition. The predominant receptor subtypes in these brain areas are M1, M3, and M4. Therefore, M1 is a potential target for cognition, Alzheimer`s, dementia, and schizophrenia. Studies on knock-out mouse models of M1 are also beginning to reveal potential functions of the receptor. Additional information on the muscarinic receptors can be found in reviews.

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사양

등록 번호NM_000738

어세이 입력Cell-based beta lactamase reporter gene

셀 상태Dividing Cells

검출 방법Fluorescence

용도(애플리케이션)FRET

유전자 기호M1

개체군 상태Single Cell Clone Origin

제품라인GeneBLAzer™

수량5 x 106 Cells

리포터 유전자BLA (Beta-Lactamase)

타겟 입력M1

세포주Jurkat

System TypeGeneBLAzer™

Druggable TargetGPCR

Unit SizeEach