Thermo Fisher Scientific FKBP15 Polyclonal Antibody
FKBP15 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, Western blot에 최적화되어 있습니다. 인간, 마우스, 랫트에서 반응하며 액상 형태로 제공됩니다. Affinity chromatography로 정제되어 안정적인 신호 검출이 가능합니다.
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Applications
- Western Blot (WB): 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human FKBP15 (Accession Q5T1M5), corresponding to amino acid residues K48–A98 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899873 |
Product Specific Information
Antibody detects endogenous levels of total FKBP135.
Target Information
FKBP15, also known as FKBP133, is a member of the FK506-binding protein family, initially identified as immunophilins—targets for the immunosuppressant drugs FK506 and Rapamycin. FKBP15 is expressed in the developing nervous system and contains a WH1-like domain in addition to the FK506-binding protein motif.
It is distributed along axonal shafts and co-localizes with F-actin in growth cones of dorsal root ganglion neurons. Overexpression increases filopodia number, suggesting FKBP15 modulates growth cone behavior.
FKBP15 associates with microtubules and actin filaments; RNAi-mediated disruption delays early endosome transport in HeLa cells, indicating a role in endosomal transport. At least three isoforms of FKBP15 are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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