Thermo Fisher Scientific Huntingtin-associated protein40 (HAP40) Polyclonal Antibody
HAP40 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot에 적합합니다. 토끼 IgG 기반 비결합형 항체이며, 1 mg/mL 농도의 액상 형태로 제공됩니다. 헌팅턴 단백질 연구 및 헌팅턴병 관련 기전 분석에 유용합니다.
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Thermo Fisher Scientific Huntingtin-associated protein40 (HAP40) Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | DGHGQDTSGQLP (a.a. 314–325) of the 40 kDa mouse HAP40 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Target Information
Huntington’s disease is caused by an expanded CAG trinucleotide repeat coding for a polyglutamine stretch within the Huntington protein. Huntington co-purifies with a single novel 40 kDa protein designated HAP40. Recombinant HAP40 is cytoplasmic in the presence of Huntington but is actively targeted to the nucleus in the absence of Huntington. These observations suggest that HAP40 contributes to the function of normal Huntington and may be involved in the aberrant nuclear localization of mutant Huntington found in degenerating neurons in Huntington’s disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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