Thermo Fisher Scientific CD20 Chimeric Recombinant Rabbit Monoclonal Antibody (B9E9)
CD20 단백질을 인식하는 재조합 토끼 단일클론 항체로, 인간 B세포 및 관련 악성 세포 연구에 적합합니다. Western blot, ICC/IF, RIA 등 다양한 응용에 사용 가능하며, 높은 특이성과 재현성을 제공합니다. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | Assay-dependent | |
| Immunocytochemistry (ICC/IF) | 1:1,000 | |
| Radioimmune Assays (RIA) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | B9E9 |
| Immunogen | This antibody was raised against human CD20. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
This antibody is specific for CD20, which is expressed by normal and malignant B cells. It does not cross-react with murine CD20.
Target Information
CD20 is a non-glycosylated surface phosphoprotein (33–37 kDa) expressed on mature and most malignant B cells, as well as a subpopulation of T lymphocytes and follicular dendritic cells. CD20 expression coincides with surface IgM and regulates calcium conductance, cell cycle progression, and B-cell proliferation. It associates with lipid rafts, with association intensity influenced by extracellular triggers and BCR aggregation. Upon receptor ligation, CD20 colocalizes with BCR and remains at the cell surface after BCR endocytosis. CD20 is a key target for antibody-mediated B-cell depletion therapy, as it is highly expressed on B-cell malignancies and remains membrane-bound following treatment. Diseases associated with CD20 dysfunction include Ms4a1-related common variable immune deficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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