Thermo Fisher Scientific Phospho-MEK1/2 (Ser218, Ser222) Polyclonal Antibody
MEK1/2 단백질의 Ser218/222 인산화 상태를 검출하는 Thermo Fisher의 rabbit polyclonal antibody. Western blot 및 ELISA에 사용 가능하며, 고순도 Protein A 정제. 세포 성장 및 MAPK 신호 연구에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:300–1:1,000
ELISA
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide derived from human MEK1 around the phosphorylation site of Ser218/222 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
MAP2K1 (MEK1) kinase is a dual-specificity protein kinase functioning in mitogen-activated protein kinase (MAPK) cascades, controlling cell growth and differentiation.
MAP2K1 is activated by various growth factors, cytokines, membrane-dependent depolarization, and calcium influx.
MEK1 activation occurs via phosphorylation at serine 218 and 222 residues by Raf1.
It plays roles in stress response signaling, apoptosis, and cytokine-induced proliferation.
Mutations in MAP2K1 can lead to cardiofaciocutaneous syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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