Thermo Fisher Scientific TRAF2 Polyclonal Antibody
TRAF2 단백질을 표적하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF, IP 등 다양한 응용 가능. 인간, 마우스, 랫트 반응성. 고순도 항원 친화 크로마토그래피 정제. 연구용으로 적합.
- 카탈로그번호
- PA520193
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific TRAF2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.5–2 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | 2.5 µg/mL | - |
| Immunocytochemistry (ICC/IF) | 20 µg/mL | - |
| Immunoprecipitation (IP) | Assay-dependent | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 16 amino acid peptide from near the amino terminus of human TRAF2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152352 |
Product Specific Information
- Suggested positive control: human liver tissue lysate
- PA5-20193 can be used with blocking peptide PEP-0323
Target Information
Tumor necrosis factor (TNF) receptor associated factors (TRAFs) are adaptor proteins that link the TNF receptor superfamily to signaling pathways, playing key roles in regulating cell death and stress responses.
TRAF proteins share a conserved region enabling receptor and TRAF interactions, activating distinct signal cascades depending on the TRAF involved.
TRAF2 and TRAF3 directly bind to CD40, a member of the NF receptor superfamily, and are critical for NF-kappa-B activation in mouse B lymphocytes.
TRAF2, together with TRAF6, is required for CD40 signaling in nonhematopoietic cells.
Additionally, TRAF2 interacts with the lymphotoxin-beta receptor (LTbetaR) alongside TRAF3 and apoptosis inhibitors cIAP1 and Smac.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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