Thermo Fisher Scientific PDPK1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human PDPK1, validated for Western blot. Recognizes peptide sequence CIQEVWRQRYQSHPDAAVQ. Supplied as liquid, unconjugated form. Stored at 4°C, suitable for metabolic and kinase signaling research.
- 카탈로그번호
- PA110039
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 2 µg/mL
- Publications: [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide corresponding to the amino acids CIQEVWRQRYQSHPDAAVQ of human PDK1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Wet ice |
| RRID | AB_11152395 |
Target Information
PDPK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDPK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. It also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), leading to dephosphorylation and activation of glycogen synthase and stimulation of glycogen synthesis.
Because of PDPK1’s role in insulin-induced glycogen synthesis and PKC activation, it is an important target for metabolic drug research.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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