Thermo Fisher Scientific PDPK1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 2 µg/mL
• Publications: [References not provided]

Product Specifications

Target Information

PDPK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDPK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. It also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), leading to dephosphorylation and activation of glycogen synthase and stimulation of glycogen synthesis.
Because of PDPK1’s role in insulin-induced glycogen synthesis and PKC activation, it is an important target for metabolic drug research.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.