Thermo Fisher Scientific MAGEC2 Polyclonal Antibody
MAGEC2 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에 적합합니다. Human, Mouse, Rat 시료에 반응하며, 고순도(>95%) 항원 친화 정제 제품입니다. PBS와 50% glycerol buffer에 보관되며, 연구용으로 사용됩니다.
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Applications
Tested Application
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 237–282 of human MAGEC2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553896 |
Product Specific Information
- Detects endogenous MAGEC2 protein at approximately 41 kDa.
- Purity >95% by SDS-PAGE.
Target Information
MAGE-C2/C3 (Melanoma-associated antigen C2, Hepatocellular carcinoma-associated antigen 587) is a 373 amino acid protein encoded by the human gene MAGEC2.
Genes of the MAGE family encode tumor antigens recognized by cytolytic T lymphocytes on human melanomas.
MAGE-C2/C3 is frequently expressed in seminomas, melanomas, and bladder transitional cell carcinomas, as well as in head and neck carcinomas, breast carcinomas, nonsmall-cell lung carcinomas, and sarcomas.
In hepatocellular carcinoma, expression inversely correlates with tumor differentiation.
MAGE-C2/C3 is not expressed in normal tissues except germ cells in seminiferous tubules and Purkinje cells of the cerebellum. It is strongly expressed in spermatogonia and primary spermatocytes, but expression decreases in mature spermatids.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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